2024
Autier B, Verger A, Plaisse C, Manuel C, Chollet-Krugler M, Preza M, Lundstroem-Stadelmann B, Amela-Cortes M, Aninat C, Samson M, Brandhonneur N, Dion S. PLGA-PEG-COOH nanoparticles are efficient systems for delivery of mefloquine to Echinococcus multilocularis metacestodes. Exp Parasitol. 2024 Aug 5:265:108811. DOI: 10.1016/j.exppara.2024.108811.
Lundström-Stadelmann B, Preza M, Kaethner M, Hemphill A. Novel chemotherapeutical approaches against echinococcosis - a Swiss view. Book chapter in Echinococcus: Control and Elimination of Echinococcosis with a Focus on China and Europe. Springer Link. 2024. Doi: 10.1007/978-3-031-54479-8.
Santoro A, Santolamazza F, Cacciò SM, La Rosa G, Antolová D, Auer H, Bagrade G, Bandelj P, Basso W, Beck R, Citterio CV, Davidson RK, Deksne G, Frey CF, Fuglei E, Glawischnig W, Gottstein B, Harna J, Huus Petersen H, Karamon J, Jansen F, Jarošová J, Jokelainen P, Lundström-Stadelmann B, Maksimov P, Miljević M, Miterpáková M, Moks E, Origgi F, Ozolina Z, Ryser MP, Romig T, Šarkūnas M, Scorrano N, Saarma U, Šnábel V, Sréter T, Umhang G, Vengušt G, Žele Vengušt D, Casulli A. Mitochondrial genetic diversity and phylogenetic relationships of Echinococcus multilocularis in Europe. Int J Parasitol. 2024 Jan 19:S0020-7519(24)00014-6. doi: 10.1016/j.ijpara.2024.01.003. Online ahead of print.
2023
Stettler M, Lotz C, Probst A, Marreros N, Lundström-Stadelmann B, Frey C, Keiser J, Hofer A, Hoby S. SAFETY AND PHARMACOKINETICS OF PRAZIQUANTEL IN EUROPEAN POND TURTLES (EMYS ORBICULARIS). Journal of Zoo and Wildlife Medicine 2023, 54(4): 728 – 737. Doi: 10.1638/2023-0031.
Kaethner M, Rennar G, Gallinger T, Kämpfer T, Hemphill A, Mäder P, Luque-Gómez A, Schlitzer M, Lundström B. In Vitro Activities of Dithiocarbamate Derivatives against Echinococcus multilocularis Metacestode Vesicles. Trop. Med. Infect. Dis. 2023, 8(12), 517; https://doi.org/10.3390/tropicalmed8120517.
Sprague D, Kaethner M, Park S-K, Rohr CM, Harris JL, Maillard D, Spangenberg T, Lundström-Stadelmann B, Marchant JS. The Anthelmintic Activity of Praziquantel Analogs Correlates with Structure–Activity Relationships at TRPMPZQ Orthologs. ACS Med. Chem. Lett. 2023, 14, 11, 1537 – 1543. doi.org/10.1021/acsmedchemlett.3c00350.
Kaethner M, Preza M, Kaempfer T, Zumstein P, Tamponi C, Varcasia A, Hemphill A, Brehm K, Lundström-Stadelmann B. Establishment and application of unbiased in vitro drug screening assays for the identification of compounds against Echinococcus granulosus sensu stricto. PLoS Negl Trop Dis. 2023 Aug 4;17(8):e0011343. doi: 10.1371/journal.pntd.0011343.
Müller J, Preza M, Kaethner M, Rufener, R, Braga S, Uldry AC, Heller M, Lundström-Stadelmann B. Targeted and non-targeted proteomics to characterize the parasite proteins of Echinococcus multilocularis metacestodes. Frontiers Cellular and Infection Microbiology. Front Cell Infect Microbiol. 2023 May 30;13:1170763. doi: 10.3389/fcimb.2023.1170763. eCollection 2023.
Memedovski R, Preza M, Müller J, Kämpfer T, Rufener R, de Soza MVN, da Silva ET, de Andrade GF, Braga S, Uldry AC, Buchs N, Heller M, Lundström-Stadelmann B. Investigation of the mechanism of action of mefloquine and derivatives against the parasite Echinococcus multilocularis. Int J Parasitology – Drugs Drug Resist. 2023 Apr;21:114-124. doi: 10.1016/j.ijpddr.2023.03.002
Autier B, Manuel C, Lundstroem-Stadelmann B, Girard JP, Gottstein B, Gangneux JP, Samson M, Robert-Gangneux F, Dion S. Endogenous IL-33 Accelerates Metacestode Growth during Late-Stage Alveolar Echinococcosis. Microbiol Spectr. 2023 Feb 14:e0423922. doi: 10.1128/spectrum.04239-22.
2022
Chaudhry S, Zurbriggen R, Preza M, Kämpfer T, Kaethner M, Memedovski R, Scorrano N, Hemphill A, Doggett JS, Lundström-Stadelmann B. Dual inhibition of the Echinococcus multilocularis energy metabolism. Frontiers in Veterinary Science. 2022 Aug 5;9:981664. doi: 10.3389/fvets.2022.981664.
Ilic N, Bojic Trbojevic Z, Lundström-Stadelmann B, Cujic D, Radovic I, Gruden-Movsesijan A. Immunomodulatory components of Trichinella spiralis excretory-secretory products with lactose-binding specificity. EXCLI Journal. Vol 21 (2022). https://doi.org/10.17179/excli2022-4954.
Weingartner M, Stücheli S, Jebbawi F, Gottstein B, Beldi G, Lundström-Stadelmann B, Wang J, Odermatt A. Albendazole reduces hepatic inflammation and endoplasmic reticulum-stress in a mouse model of chronic Echinococcus multilocularis infection. PLoS NTD. 2022 Jan 14;16(1):e0009192. doi: 10.1371/journal.pntd.0009192.
Frey CF, Basso WU, Zürcher-Giovanni S, Marti I, Borel St, Guthruf S, Gliga D, Lundström-Stadelmann B, Origgi FC, Ryser Degiorgis MP. The golden jackal (Canis aureus): A new host for Echinococcus multilocularis and Trichinella britovi in Switzerland. Schweiz Arch Tierheilkd. 2022 Jan;164(1):71-78. doi: 10.17236/sat00338.
2021
Karpstein T*, Chaudhry S*, Bresson-Hadni S, Hayoz, M, Boubaker G, Hemphill, A, Rufener R, Schindler I, Aebi Y, Largiader C, Lundström-Stadelmann B. Maca against echinococcosis? - A reverse approach from patient to in vitro drug testing. Pathogens. 2021 Oct 15;10(10):1335. doi: 10.3390/pathogens10101335.
Basso WU, Marreros N, Hofmann L, Salvisberg C, Lundström-Stadelmann B, Frey CF. Evaluation of the PrioCHECK™ Trichinella AAD kit to detect Trichinella spiralis, T. britovi, and T. pseudospiralis larvae in pork using the automated digestion method Trichomatic-35. Parasitol Int. 2021 Sep 2;86:102449. doi: 10.1016/j.parint.2021.102449.
Gomez C, Jebbawi F, Weingartner M, Wang J, Stücheli S, Stieger B, Gottstein B, Beldi G, Lundström-Stadelmann B, Odermatt, A. Impact on serum bile acid concentrations by alveolar echinococcosis and treatment with albendazole in mice. Metabolites. 2021 Jul 6;11(7):442. doi: 10.3390/metabo11070442.
Hemphill A, Lundström-Stadelmann B. Echinococcus - the model cestode parasite. Parasitology. Editorial. doi.org/10.1017/S003118202100113X.
Jebbawi F, Bellanger A-P, Lundström-Stadelmann B, Rufener R, Dosch M, Goepfert C, Gottstein B, Millon L, Gradgirard D, Leib SL, Beldi G, Wang J. Innate and adaptive immune responses following PD-L1 blockade in treating chronic murine alveolar echinococcosis. Parasite Immunol. 2021 Mar 23;e12834. doi: 10.1111/pim.12834.
2020
Wang J, Marreros N, Rufener R, Hemphill A, Gottstein B, Lundström-Stadelmann B. Efficacy of albendazole against alveolar echinococcosis is depending on the immune system. Exp Parasitol. Oct 2020: 219:108013. doi: 10.1016/j.exppara.2020.108013.
Lundström-Stadelmann B, Rufener R, Hemphill A. Drug repurposing applied: activity of the anti-malarial mefloquine against Echinococcus multilocularis. Int. J. Parasitol. Drugs Drug Resist. Aug 2020: Vol 13, 121-129. https://doi.org/10.1016/j.ijpddr.2020.06.002
Vural G, Yardimci M, Kocak M, Yasar TÖ, Kurt A, Harem IS, Carradori S, Sciamanna I, Siles-Lucas M, Fabiani M, Hemphill A, Lundström-Stadelmann B, Cirilli R, Casulli A. Efficacy of novel albendazole salt formulations against secondary cystic echinococcosis in experimentally infected mice. Parasitology. 2020, Jul 30; 1-8. doi: 10.1017/S0031182020001225.
Ritler, D., Marreros, N., Lundström-Stadelmann, B., 2020. IC50. Github.
2019
Ritler D, Rufener, R, Li JV, Kämpfer U, Müller J, Bühr C, Schürch S, Lundström-Stadelmann B. In vitro metabolomic footprint of the Echinococcus multilocularis metacestode. Sci Rep. 2019 Dec 19;9(1):19438. doi: 10.1038/s41598-019-56073-y.
Hemphill A, Rufener R, Ritler D, Dick L, Lundström-Stadelmann B. Drug Discovery and Development for the Treatment of Echinococcosis, Caused by the Tapeworms Echinococcus granulosus and Echinococcus multilocularis. In: Neglected Tropical Diseases: drug discovery and development (ed, David C Swinney, Michael Pollastri). 2019, pp. 251-286. Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany.
Frey C, Jenkins E, Lundström-Stadelmann B. Editorial overview: From farms and forests to forks? A review of diagnosis and management of globally important zoonotic Echinococcus spp. cestodes. FAWPAR. Volume 16, Sept 2019. doi.org/10.1016/j.fawpar.2019.e00061.
Hizem A, Lundström-Stadelmann B, M’rad S, Souier S, Jannet HB, Flamini G, Ghedira K, Babba H, Hemphill A. In vitro activity of Thymus capitatus essential oil against Echinococcus multilocularis metacestodes. Parasitology. Apr 12:1-12. doi: 10.1017/S0031182019000295.
Lundström-Stadelmann B, Rufener R, Ritler D, Zurbriggen R, Hemphill A. The importance of being parasiticidal… and update on drug development for the treatment of alveolar echinococcosis. FAWPAR. 2019 Mar 14. E00040. doi: 10.1016/j.fawpar.2019.e00040.
2018
Rufener R, Dick L, D'Ascoli L, Ritler D, Hizem A, Wells TNC, Hemphill A, Lundström-Stadelmann B. Repurposing of an old drug: In vitro and in vivo efficacies of Buparvaquone against Echinococcus multilocularis. Int J Parasitol. 2018 Dec. doi: 10.1016/j.ijpddr.2018.10.011.
Wang J, Cardoso R, Marreros N, Müller N, Lundström-Stadelmann B, Siffert M, Vuitton DA, Boué F, Lin R, Wen H, Gottstein B. 2018. Foxp3+ Tregs as a potential target for immunotherapy against primary infection with Echinococcus multilocularis eggs. Infect Immun. 2018 Jul 23. pii: IAI.00542-18. doi: 10.1128/IAI.00542-18.
Rufener R, Ritler D, Zielinski J, Dick L, da Silva ET, da Silva Araujo A, Joekel DE, Czock D, Goepfert C, Marques Moraes A, de Souza MVN, Müller J, Mevissen M, Hemphill A, Lundström-Stadelmann B. 2018. Activity of mefloquine and mefloquine derivatives against Echinococcus multilocularis. International Journal of Parasitology Drugs and Drug Resistance. doi.org/10.1016/j.ijpddr.2018.06.004.
Joekel DE, Lundström-Stadelmann B, Müllhaupt B, Hemphill A, Deplazes P. Evaluation of kinase-inhibitors nilotinib and everolimus against alveolar echinococcosis in vitro and in a mouse model. Experimental Parasitology. 2018. Apr 3. pii: S0014-4894(17)30572-6. doi: 10.1016/j.exppara.2018.04.002.
Liu J, Peirasmaki D, Ma’ayeh S, Lundström-Stadelmann B, Hellman L and SG Svärd. Secreted Giardia intestinalis cysteine proteases disrupt intestinal epithelial cell junctional complexes and degrade chemokines. Virulence. 2018; 9(1): 879–894. doi: 10.1080/21505594.2018.1451284.
Lundström-Stadelmann B. Strategies for the identification of novel treatment options against parasitic diseases. 2018. Habilitation thesis. Vetsuisse Faculty, University of Bern, Switzerland.
2017
Leitsch D, Rout S, Lundström-Stadelmann B, Balmer V, Hehl A and N Müller. Giardia lamblia: missing evidence for a canonical thioredoxin system. Parasitology Open. 2017. doi: 10.1017/pao.2017.16.
Ritler D, Rufener R, Sager H, Bouvier J, Hemphill A and B Lundström-Stadelmann. Development of a movement-based in vitro screening assay for the identification of new anti-cestodal compounds. PLoS Negl Trop Dis. 2017 May 17;11(5):e0005618. doi: 10.1371/journal.pntd.0005618.
Gorgas D, Marreros N, Rufener R, Hemphill A and B Lundström-Stadelmann. To see or not to see: non-invasive imaging for improved readout of drug treatment trials in the murine model of secondary alveolar echinococcosis. Parasitology. 2017 Jun;144(7):937-944. doi: 10.1017/S0031182017000051.
2016
Stadelmann B, Rufener R, Aeschbacher D, Spiliotis M, Gottstein B, Hemphill A. Screening of the Open Source Malaria Box Reveals an Early Lead Compound for the Treatment of Alveolar Echinococcosis. PLoS NTD. 2016. Mar 11;10(3):e0004535. doi: 10.1371/journal.pntd.0004535.
2015
Küster T*,Stadelmann B*, Rufener R, Risch C, Müller J, Hemphill A. Oral treatments of Echinococcus multilocularis-infected mice with the antimalarial drug mefloquine that potentially interacts with parasite ferritin and cystatin. Int J Antimicrob Agents. 2015 Nov;46(5):546-51. doi: 10.1016/j.ijantimicag.2015.07.016.
2014
Hemphill A, Stadelmann B, Rufener R, Spiliotis M, Boubaker G, Müller J, Müller N, Gorgas D, Gottstein B. Treatment of echinococcosis: albendazole and mebendazole--what else? Parasite. 2014. doi: 10.1051/parasite/2014073.
Stadelmann B, Aeschbacher D, Huber C, Spiliotis M, Müller J, Hemphill A. Profound Activity of the Anti-cancer Drug Bortezomib against Echinococcus multilocularis Metacestodes Identifies the Proteasome as a Novel Drug Target for Cestodes. PLoS Neglected Tropical Diseases. 2014 Dec 4; 8(12):e3352. doi: 10.1371/journal.pntd.0003352.
Hemer S, Konrad C, Spiliotis M, Schaack D, Förster S, Gelmedin V, Stadelmann B, Dandekar T, Hemphill A, Brehm K. Host insulin stimulates Echinococcus multilocularis insulin signalling pathways and larval development. BMC Biology. 2014. Jan 27; 12:5. doi: 10.1186/1741-7007-12-5.
Küster T, Stadelmann B, Aeschbacher D, Hemphill A. Activities of fenbendazole in comparison with albendazole against Echinococcus multilocularis metacestodes in vitro and in a murine infection model. International Journal of Antimicrobial Agents. 2014.Apr;43(4):335-42. doi: 10.1016/j.ijantimicag.2014.01.013.
Stadelmann B, Hanevik K, Andersson MK, Bruserud O, Svärd SG. The role of arginine and arginine-metabolizing enzymes during Giardia -- host cell interactions in vitro. BMC microbiology. 2013 Nov 14; 13:256. doi: 10.1186/1471-2180-13-256.
Küster T, Kriegel N, Stadelmann B, Wang X, Dong Y, Vennerstrom J, Keiser, Hemphill A. Amino ozonides exhibit in vitro activity against Echinococcus multilocularis metacestodes. International Journal of Antimicrobial Agents. 2014 Jan; 43(1):40-6. doi: 10.1016/j.ijantimicag.2013.09.012.
2012
Stadelmann B, Merino MC, Persson L, Svärd SG. Arginine consumption by the intestinal parasite Giardia intestinalis reduces proliferation of intestinal epithelial cells. PLoS One. 2012; 7(9). doi: 10.1371/journal.pone.0045325.
Jerlström-Hultqvist J, Stadelmann B, Birkestedt S, Hellman U, Svärd SG. Plasmid vectors for proteomic analyses in Giardia: purification of virulence factors and analysis of the proteasome. Eukaryotic Cell. 2012 Jul; 11(7):864-73. doi: 10.1128/EC.00092-12.
2011
Stadelmann B*, Küster T*, Scholl S, Barna F, Kropf C, Keiser J, Boykin DW, Stephens CE, Hemphill A. In vitro efficacy of di-cationic compounds and mefloquine-enantiomers against Echinococcus multilocularis metacestodes. Antimicrobial Agents and Chemotherapy. 2011 Oct; 55(10):4866-72. doi: 10.1128/AAC.00478-11.
Küster T*, Stadelmann B*, Hermann C, Scholl S, Keiser J, Hemphill A. In vitro and in vivo efficacies of mefloquine-based treatment against alveolar echinococcosis. Antimicrobial Agents and Chemotherapy. 2011 Feb; 55(2):713-21. doi: 10.1128/AAC.01392-10.
2010
Stadelmann B, Spiliotis M, Müller J, Scholl S, Müller N, Gottstein B, Hemphill A. Echinococcus multilocularis phosphoglucose isomerase (EmPGI): a glycolytic enzyme involved in metacestode growth and parasite-host cell interactions. International Journal of Parasitology. 2010 Nov; 40(13):1563-74. doi: 10.1016/j.ijpara.2010.05.009.
Stadelmann B, Scholl S, Müller J, Hemphill A. Application of an in vitro drug screening assay based on the release of phosphoglucose isomerase to determine the structure-activity relationship of thiazolides against Echinococcus multilocularis metacestodes. Journal of Antimicrobial Chemotherapy. 2010 Mar; 65(3):512-9. doi: 10.1093/jac/dkp490.
Stadelmann B. “To be or not to be”: the importance and application of EmPGI in alveolar echinococcosis. 2010. PhD thesis, Vetsuisse Faculty and Faculty of Medicine, University of Berne, Switzerland. http://www.zb.unibe.ch/download/eldiss/10stadelmann_b.pdf
2009
Hemphill A, Stadelmann B, Scholl S, Müller J, Spiliotis M, Müller N, Gottstein B, Siles-Lucas M. Echinococcus metacestodes as laboratory models for the screening of drugs against cestodes and trematodes. Parasitology. 2010 Mar; 137(3):569-87. doi: 10.1017/S003118200999117X.
Müller J, Limban C, Stadelmann B, Missir AV, Chirita IC, Chifiriuc MC, Nitulescu GM, Hemphill A. Thioureides of 2-(phenoxymethyl)benzoic acid 4-R substituted: a novel class of anti-parasitic compounds. Parasitology International. 2009 Jun; 58(2):128-35. doi: 10.1016/j.parint.2008.
2008
Spicher M, Roethlisberger C, Lany C, Stadelmann B, Keiser J, Ortega-Mora LM, Gottstein B, Hemphill A. In vitro and in vivo treatments of echinococcus protoscoleces and metacestodes with artemisinin and artemisinin derivatives. Antimicrobial Agents and Chemotherapy. 2008 Sep; 52(9):3447-50. doi: 10.1128/AAC.00553-08.
2007
Hemphill A, Spicher M, Stadelmann B, Mueller J, Naguleswaran A, Gottstein B, Walker M. Innovative chemotherapeutical treatment options for alveolar and cystic echinococcosis. Parasitology. 2007 Nov;134 (Pt 12):1657-70. Epub 2007 Jul 16. doi: 10.1017/S0031182007003198.
